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In epidemiology, particularly in the discussion of infectious disease dynamics (modeling), the latent period (also known as the latency period or the pre-infectious period) is the time interval between when an individual or host is infection by a pathogen and when that individual becomes infectious, i.e. capable of transmitting pathogens to other susceptible individuals.
The infection of a disease begins when a pathogenic (disease-causing) infectious agent, or a pathogen, is successfully transmitted from one host to another. Pathogens leave the body of one host through a portal of exit, are carried by some mode of transmission and after coming into contact (exposure) with a new susceptible host, they enter the host's body through an appropriate portal of entry. Upon entering the new host, they take a period of time to overcome or evade the immune response of the body and to multiply or replicate after having traveled to their favored sites within the host’s body (tissue invasion and tropism). When the pathogens become sufficiently numerous and toxic to cause damage to the body, the host begins to display of a clinical disease (i.e. the host becomes symptomatic).
The period from the time of infection to the time of becoming infectious is called the pre-infectious period or the latent period. During the pre-infectious or latent period, a host may or may not show symptoms (i.e. the incubation period may or may not be over), but in both cases, the host is not capable of infecting other hosts i.e. transmitting pathogens to other hosts. The latent period, rather than the incubation period, has more influence on the spreading dynamics of an infectious disease or epidemic.
However, for some infectious diseases, the symptoms of the clinical disease may appear after the host becomes infectious. In this case, the pre-infectious or latent period has a shorter duration than the incubation period, the infectious period begins before the end of the incubation period and the host can infect others for some time without showing any noticeable symptoms. This early or mild stage of infection whose symptoms stay below the level of clinical detection is called subclinical infection and the individual concerned is called an asymptomatic carrier of the disease. For example, in HIV/AIDS, the incubation period lasts years longer than the latent period. So an HIV infected individual can show no symptoms and unwittingly infect other susceptible individuals for many years. In COVID-19, the infectious period begins approximately 2 days before the onset of symptoms and 44% of the secondary infections may happen during this pre-symptomatic stage. In these kinds of cases with a significant number of pre-symptomatic (asymptomatic) transmissions, symptomatic surveillance-based disease control measures (such as isolation, contact tracing, enhanced hygiene, etc.) are likely to have their effectiveness reduced, because a significant portion of the transmission may take place before the onset of symptoms and this has to be taken into account when designing control measures.
The infectious period is a very important element in the infectious disease spreading dynamics. If the infectious period is long, then the measure of secondary infections (represented by the basic reproduction number, R0) will generally be larger, regardless of the infectiousness of the disease. For example, even though HIV/AIDS has a very low transmission potential per sexual act, its basic reproduction number is still very high because of its unusually long infectious period spanning many years. From the viewpoint of controlling an epidemic, the goal is to reduce the effective infectious period either by treatment or by isolating the patient from the community. Sometimes a treatment can paradoxically increase the effective infectious period by preventing death through supportive care and thereby increasing the probability of infection of other individuals.
Since the precise moment of infection is very difficult and almost impossible to detect, the generation time is not properly observable for two successive hosts. Generally, in infectious disease statistics, the onset of clinical symptoms for all the hosts are reported. For two successive generations (or cases or hosts) in a chain of infection, the serial interval is defined as the period of time between the onset of clinical symptoms in the first host (infector) and the onset of analogous clinical symptoms in the second host (infectee). Just like the generation time, the length of the serial interval depends on the lengths of the latent period, the infectious period and the incubation period. Therefore the serial interval is often used as a proxy measure to estimate the generation time.
In the discussion of (a non-infectious disease), the term "latency period" is used to indicate the time that passes between being exposed to something that can cause disease (such as radiation or a virus) and having symptoms. Doctors and medical journals may speak of "latent" tumors, which are present but not active or causing symptoms.
In the discussion of syphilis (a sexually transmitted infectious disease), the term "latent" refers to asymptomatic periods with different degrees of infectiousness.
Usage of the term outside epidemiology
Outside the confines of epidemiology, the term "latent period" may be defined in some general-purpose dictionaries (e.g. the Collins English Dictionary or Merriam-Webster Online Dictionary) as being the time interval between infection by a pathogen and the onset of symptoms, i.e., as a synonymous term for the epidemiologically different concept of "incubation period".
See also
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